Sleep and wakefulness modulate gene expression inDrosophila
نویسندگان
چکیده
منابع مشابه
Gene expression during sleep, wakefulness and sleep deprivation.
Studies conducted on genes expression through the sleep-wake cycle and after sleep deprivation have revealed a number of genes that are more active during wakefulness/prolonged wakefulness than sleep, but also a few genes that are more active during sleep than wakefulness. Gene expression profiles during a specific vigilance state can be effectively monitored using microarrays, and when compari...
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Sleep is present in all species where it has been studied, but its functions remain unknown. To investigate what benefits sleep may bring at the cellular level, we profiled gene expression in awake and sleeping rats by using high-density microarrays. We find that approximately 10% of the transcripts in the cerebral cortex change their expression between day and night and demonstrate that half o...
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Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic function as well as impaired immune response. Using high-resolution microarrays we evaluated the gene expression profiles of healthy male volunteers w...
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This review summarizes the brain mechanisms controlling sleep and wakefulness. Wakefulness promoting systems cause low-voltage, fast activity in the electroencephalogram (EEG). Multiple interacting neurotransmitter systems in the brain stem, hypothalamus, and basal forebrain converge onto common effector systems in the thalamus and cortex. Sleep results from the inhibition of wake-promoting sys...
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Neurons in many regions of the lower brain are chemosensitive in vitro. Focal acidification of these same and other regions in vivo can stimulate breathing indicating the presence of chemoreception. Why are there so many sites for central chemoreception? This review evaluates data obtained from unanesthetized rats at three central chemoreceptor sites, the retrotrapezoid nucleus (RTN), the medul...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2005
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2005.03291.x